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| Nomenclature |
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Symbol:
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Tg(Camk2a-MAPT*R406W)748Atak
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Name:
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transgene insertion 748, Akihiko Takashima
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MGI ID: |
MGI:3603948 |
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Transgene:
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Tg(Camk2a-MAPT*R406W)748Atak
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x SJL
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: An 8.5 kb portion of the calcium/calmodulin-dependent protein kinase II alpha promoter was used to drive the human microtubule-associated protein tau with the R406W mutation postnataly in forebrain neurons. Protein was expressed the greatest in the hippocampus, followed in decreasing amounts by the neocortex, the olfactory bulb, the striatum, and the thalamus. Mutant protein was barely detectable in the midbrain, the cerebellum and the spinal cord. Lines 502, 492 and 483 demonstrated similar expression patterns. (J:100958)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:100958
Tatebayashi Y et al.,
"Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau."
Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13896-901
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All: |
2 reference(s)
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Analysis Tools
