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| Nomenclature |
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Symbol:
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Kittm1Bpr
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Name:
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kit oncogene;
targeted mutation 1, Brian P Rubin
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MGI ID: |
MGI:3603004 |
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Synonyms: |
KitK641E:Neo |
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Gene:
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Kit
Location:
Chr5:75574916-75656722 bp, + strand
Genetic Position: Chr5,
39.55 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:100778
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting construct was designed to introduce a lysine to glutamic acid mutation at amino acid position 641 in exon 13. A loxP flanked neomycin resistance gene was included in the targeting vector in intron 13. Position 641 is within the first portion of the slpit kinase domain. (J:100778)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:100778
Rubin BP et al.,
"A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E."
Cancer Res 2005 Aug 1;65(15):6631-9
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All: |
1 reference(s)
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Analysis Tools
