|
|
| Nomenclature |
|
Symbol:
|
Abca1tm1.1Jp
|
|
Name:
|
ATP-binding cassette, sub-family A (ABC1), member 1;
targeted mutation 1.1, John S Parks
|
|
MGI ID: |
MGI:3577725 |
|
Synonyms: |
Abca1- |
|
Gene:
|
Abca1
Location:
Chr4:53030787-53159895 bp, - strand
Genetic Position: Chr4,
28.57 cM, cytoband A5-B3
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:98093
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Intragenic deletion |
| |
|
Abca1tm1Jp mice were crossed with Tg(EIIa-cre)C5379Lmgd mice to remove exons 45 and 46. (J:98093)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Abca1 Mutation:
|
9 strains or lines available |
|
| References |
|
Original: |
J:98093
Timmins JM et al.,
"Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I."
J Clin Invest 2005 May 2;115(5):1333-1342
|
|
All: |
3 reference(s)
|
|
Analysis Tools
