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| Nomenclature |
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Symbol:
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Sh2d1atm1Cpt
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Name:
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SH2 domain protein 1A;
targeted mutation 1, Cox Terhorst
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MGI ID: |
MGI:3576262 |
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Synonyms: |
SAP-, SAPKO, SH2D1A- |
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Gene:
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Sh2d1a
Location:
ChrX:42502453-42523697 bp, + strand
Genetic Position: ChrX,
23.2 cM, cytoband A5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:97756
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced exon 1. Absence of transcript was confirmed in mutant spleen and thymus via RT-PCR and absence of protein in mutant thymus was demonstrated by immunoblotting. (J:97756)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sh2d1a Mutation:
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1 strain or line available |
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| References |
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Original: |
J:97756
Wu C et al.,
"SAP controls T cell responses to virus and terminal differentiation of TH2 cells."
Nat Immunol 2001 May;2(5):410-4
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All: |
14 reference(s)
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Analysis Tools
