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| Nomenclature |
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Symbol:
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Egr2tm1Jmi
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Name:
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early growth response 2;
targeted mutation 1, Jeffrey Milbrandt
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MGI ID: |
MGI:3574072 |
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Synonyms: |
Egr2lo |
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Gene:
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Egr2
Location:
Chr10:67535475-67542188 bp, + strand
Genetic Position: Chr10,
34.96 cM, cytoband B5
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Runted phenotype and hindbrain defect of Egr2tm1Jmi/Egr2tm1Jmi mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96641
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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This hypomorphic allele resulted from the insertion of a PGK-neo was inserted into intron 1. (J:96641)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Egr2 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:96641
Le N et al.,
"Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination."
Proc Natl Acad Sci U S A 2005 Feb 15;102(7):2596-601
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All: |
3 reference(s)
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Analysis Tools
