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| Nomenclature |
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Symbol:
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Tg(Ins2-GP)34-20Olds
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Name:
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transgene insertion 34-20, Michael BA Oldstone, MD
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MGI ID: |
MGI:3573699 |
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Synonyms: |
LCMV GP, RIP GP34-20, RIP-GP34-20, RIP GP H2b, RIP-LCMV GP |
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Transgene:
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Tg(Ins2-GP)34-20Olds
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x BALB/Wehi)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene encodes the glycoprotein (GP) from Armstrong's clone of the lymphocytic choriomeningitis virus (LCMV) regulated by the rat insulin promoter. Upstream of the GP cDNA are 660 base pairs of regulatory elements in addition to the rat insulin promoter. Downstream of the GP c-DNA is the SV40 small T-antigen intron and late polyadenylation signal. RT-PCR analysis demonstrated that the transcript was expressed in the pancreas but not the thymus, spleen, liver, kidney, heart, muscle or lung. (J:81287)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:81287
von Herrath MG et al.,
"How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model."
Immunity 1994 Jun;1(3):231-42
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All: |
15 reference(s)
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Analysis Tools
