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| Nomenclature |
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Symbol:
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Nod2tm1Mka
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Name:
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nucleotide-binding oligomerization domain containing 2;
targeted mutation 1, Michael Karin
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MGI ID: |
MGI:3530578 |
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Synonyms: |
Nod22939, Nod2mt |
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Gene:
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Nod2
Location:
Chr8:88647315-88688474 bp, + strand
Genetic Position: Chr8,
43.51 cM, cytoband C3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96128
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: A cytosine was inserted at 2939 in exon 11 of the ORF, resulting in a frame-shift leading to a premature stop codon and a truncated protein. The targeting vector contained a neo downstream of the inserted cytosine. RT-PCR and Western blot confirmed successful recombination. (J:96128)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nod2 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:96128
Maeda S et al.,
"Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing."
Science 2005 Feb 4;307(5710):734-8
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All: |
3 reference(s)
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Analysis Tools
