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| Nomenclature |
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Symbol:
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Ndufs4tm1Rpa
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Name:
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NADH dehydrogenase (ubiquinone) Fe-S protein 4;
targeted mutation 1, Richard D Palmiter
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MGI ID: |
MGI:3527173 |
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Synonyms: |
Ndufs4lox |
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Gene:
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Ndufs4
Location:
Chr13:114287795-114388094 bp, - strand
Genetic Position: Chr13,
64.12 cM, cytoband D2.2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134334
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Germ line, flp mediated recombination was used to remove the neo cassette. Exon 2 contains the mitochondrial targeting sequence. (J:134334)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ndufs4 Mutation:
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16 strains or lines available |
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| References |
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Original: |
J:134334
Kruse SE et al.,
"Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy."
Cell Metab 2008 Apr;7(4):312-20
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All: |
5 reference(s)
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Analysis Tools
