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| Nomenclature |
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Symbol:
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Als2tm1Cai
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Name:
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amyotrophic lateral sclerosis 2 (juvenile);
targeted mutation 1, Huaibin Cai
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MGI ID: |
MGI:3522476 |
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Synonyms: |
ALS2- |
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Gene:
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Als2
Location:
Chr1:59162926-59237231 bp, - strand
Genetic Position: Chr1,
29.33 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:100336
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 39 bp BamHI fragment in the 1st coding exon of ALS2 was replaced with a lacZ gene and selection marker flanked with loxP sites. QPCR and Western blot analysis confirmed the absence of transcription and translation. (J:100336)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:100336
Cai H et al.,
"Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress."
J Neurosci 2005 Aug 17;25(33):7567-74
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All: |
4 reference(s)
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Analysis Tools
