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| Nomenclature |
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Symbol:
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Apctm2.1Cip
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Name:
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adenomatosis polyposis coli;
targeted mutation 2, Christine Perret
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MGI ID: |
MGI:3521822 |
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Synonyms: |
Apc2lox14, Apcfle14, Apclox, Apctm2Cpe |
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Gene:
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Apc
Location:
Chr18:34220924-34318608 bp, + strand
Genetic Position: Chr18,
18.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94721
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted into intron 13 and a loxP flanked PGK-Hprt cassette into intron 14. Cre mediated recombination removed a floxed HPRT cassette that was inserted into exon 14, leaving exon 14 flanked with loxP sites. (J:94721)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:94721
Colnot S et al.,
"Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas."
Proc Natl Acad Sci U S A 2004 Dec 7;101(49):17216-21
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All: |
11 reference(s)
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Analysis Tools
