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| Nomenclature |
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Symbol:
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Pank2tm1Jgt
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Name:
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pantothenate kinase 2;
targeted mutation 1, Jane Gitschier
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MGI ID: |
MGI:3514020 |
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Synonyms: |
Pank2- |
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Gene:
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Pank2
Location:
Chr2:131262495-131299188 bp, + strand
Genetic Position: Chr2,
63.31 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94753
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 2.3 kb fragment containing half of exon 2 and part of intron 2 was replaced with a lacZ and neomycin resistance cassette driven by the polII promoter. RT-PCR and Western blot analysis confirmed the absence of transcription and translation products. (J:94753)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pank2 Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:94753
Kuo YM et al.,
"Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia."
Hum Mol Genet 2005 Jan 1;14(1):49-57
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All: |
2 reference(s)
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Analysis Tools
