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| Nomenclature |
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Symbol:
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Htra2tm1Jdo
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Name:
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HtrA serine peptidase 2;
targeted mutation 1, Julian Downward
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MGI ID: |
MGI:3512633 |
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Synonyms: |
HtrA2/Omi- |
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Gene:
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Htra2
Location:
Chr6:83051266-83055273 bp, - strand
Genetic Position: Chr6,
35.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94227
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129P/Ola
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neo gene replaced part of exon 1, exons 2 to 6, and part of exon 7 via homologous recombination, removing 83% of the coding sequence including the proteolytic catalytic site. Western blot analysis confirmed absence of protein in MEFs (J:94227)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Htra2 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:94227
Martins LM et al.,
"Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice."
Mol Cell Biol 2004 Nov;24(22):9848-62
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All: |
4 reference(s)
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Analysis Tools
