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| Nomenclature |
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Symbol:
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Tg(Ins2-Irs2)13Mfw
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Name:
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transgene insertion 13, Morris F White
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MGI ID: |
MGI:3510672 |
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Synonyms: |
rip13Irs2 |
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Transgene:
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Tg(Ins2-Irs2)13Mfw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the Irs2 gene with a FLAG tag at the C terminus driven by the rat insulin II promoter. Two transgenes (lines 9 and 13) were analyzed based on expression level. This transgene expressed a high level of Irs2. Overexpression of the transgene was verified by Western blot analysis of islet extracts, immunostaining of pancreas and by an increase in the pancreatic insulin content. (J:94000)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:94000
Hennige AM et al.,
"Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes."
J Clin Invest 2003 Nov;112(10):1521-32
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All: |
5 reference(s)
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Analysis Tools
