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| Nomenclature |
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Symbol:
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Pax3tm1Mrc
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Name:
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paired box gene 3;
targeted mutation 1, Mario R Capecchi
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MGI ID: |
MGI:3487369 |
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Synonyms: |
Pax3:Fkhr, Pax3P3Fm |
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Gene:
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Pax3
Location:
Chr1:78101267-78197134 bp, - strand
Genetic Position: Chr1,
39.79 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:93444
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was inserted into the 3' region of the gene, resulting in loxP sites flanking exons 8-10 as well as an inserted polyA/stop signal from the C2 gene. Crossing with FLP expressing mice excised an FRT flanked neo. The mutation allowed normal functioning until activation of Cre recombinase. Cre causes the fusion of exons 1-7 of Pax3 to a region of Foxo1 containing exons 2 and 3, as well as 6.5 kb of the UTR and genomic sequence. Simultaneously, an IRES-eYfp marker is expressed. (J:93444)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pax3 Mutation:
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20 strains or lines available |
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| References |
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Original: |
J:93444
Keller C et al.,
"Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function."
Genes Dev 2004 Dec 1;18(21):2614-26
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All: |
7 reference(s)
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Analysis Tools
