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| Nomenclature |
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Symbol:
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Lrp1btm1Her
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Name:
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low density lipoprotein-related protein 1B (deleted in tumors);
targeted mutation 1, Joachim Herz
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MGI ID: |
MGI:3045402 |
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Synonyms: |
Lrp1b- |
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Gene:
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Lrp1b
Location:
Chr2:40595248-42653598 bp, - strand
Genetic Position: Chr2,
24.51 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90197
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 88, which encodes the membrane-spanning segment, was replaced with a neo. Allele-specific PCR was used to detect the gene disruption and Western blot confirmed absence of the protein in mutant brains. (J:90197)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lrp1b Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:90197
Marschang P et al.,
"Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1."
Mol Cell Biol 2004 May;24(9):3782-93
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All: |
1 reference(s)
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Analysis Tools
