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| Nomenclature |
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Symbol:
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Trp53tm2Tyj
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Name:
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transformation related protein 53;
targeted mutation 2, Tyler Jacks
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MGI ID: |
MGI:3039263 |
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Synonyms: |
LSL-Trp53R172H, p53LSL(dot)R172H, p53LSL-R172H, p53 LSL-R172H |
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Gene:
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Trp53
Location:
Chr11:69580359-69591873 bp, + strand
Genetic Position: Chr11,
42.83 cM, cytoband B2-C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:95316
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting construct was designed to insert a loxP flanked stop cassette into intron 1 and an R172H missense mutation into exon 5. (J:95316)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:95316
Olive KP et al.,
"Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome."
Cell 2004 Dec 17;119(6):847-60
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All: |
26 reference(s)
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Analysis Tools
