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| Nomenclature |
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Symbol:
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Aspatm1Mata
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Name:
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aspartoacylase;
targeted mutation 1, Reuben Matalon
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MGI ID: |
MGI:3038539 |
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Synonyms: |
CD |
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Gene:
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Aspa
Location:
Chr11:73304992-73326807 bp, - strand
Genetic Position: Chr11,
45.28 cM, cytoband B4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89100
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Parent Cell Line:
| Lex-1 (ES Cell) |
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Strain of Origin:
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129S5/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by the insertion of an IRES Beta-geo with a 10 bp deletion in exon 4 of Aspa. Beta-galactosidase expression under control of the Aspa promoter is maintained in the mutant allele. (J:89100)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Aspa Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:89100
Matalon R et al.,
"Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system."
J Gene Med 2000 May-Jun;2(3):165-75
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All: |
10 reference(s)
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Analysis Tools
