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| Nomenclature |
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Symbol:
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Gata1tm1Mym
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Name:
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GATA binding protein 1;
targeted mutation 1, Masayuki Yamamoto
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MGI ID: |
MGI:3038080 |
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Synonyms: |
GATA-1.05, GATA1.05, GataG1.05 |
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Gene:
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Gata1
Location:
ChrX:7959260-7978071 bp, - strand
Genetic Position: ChrX,
3.59 cM, cytoband A2
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Variable phenotypes of Gata1tm1Mym/Gata1+ female embryos including anemia and reduced number of hematopoietic cells
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40321
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutation: | |
Insertion |
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Mutation details: In order to weaken activity of the erythroid-specific promoter, homologous recombination was used to insert a neo cassette into the intergenic region between a GATA motif known to positively regulate transcription and the first erythroid specific exon (IE). The GATA is located approximately 620 bp 5' to IE. RT-PCR showed that gene expression in mutant male embryos was less than 5% of the level of expression in wild-type embryos. (J:40321)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gata1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:40321
Takahashi S et al.,
"Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene."
J Biol Chem 1997 May 9;272(19):12611-5
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All: |
15 reference(s)
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Analysis Tools
