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| Nomenclature |
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Symbol:
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Cacna1atm1Maag
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Name:
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calcium channel, voltage-dependent, P/Q type, alpha 1A subunit;
targeted mutation 1, Arn van den Maagdenberg
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MGI ID: |
MGI:3037859 |
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Synonyms: |
FHM-1, R192Q |
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Gene:
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Cacna1a
Location:
Chr8:84388440-84640246 bp, + strand
Genetic Position: Chr8,
40.95 cM
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Neurological deficits after spreading depression in Cacna1atm1Maag/Cacna1atm1Maag and Cacna1atm3Maag/Cacna1atm3Maag mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88693
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The human mutation R192Q was knocked in to exon 4 via homologous recombination along with a floxed neo cassette. Mice carrying both the R129Q and the floxed neo were fertile and showed no overt phenotype. Crossing with Tg(EIIa-cre)C5379Lmgd mice removed the neo cassette. The presence of the R192Q mutation in the resulting animals was confirmed by PCR and restriction enzyme digestion. Semi-quantitative Western blot analysis indicated that the mutant protein was expressed as well as the normal protein. (J:88693)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cacna1a Mutation:
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43 strains or lines available |
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| References |
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Original: |
J:88693
van den Maagdenberg AM et al.,
"A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression."
Neuron 2004 Mar 4;41(5):701-10
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All: |
9 reference(s)
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Analysis Tools
