|
|
| Nomenclature |
|
Symbol:
|
Foxl2tm1Tre
|
|
Name:
|
forkhead box L2;
targeted mutation 1, Mathias Treier
|
|
MGI ID: |
MGI:3029503 |
|
Synonyms: |
Foxl2lacZ |
|
Gene:
|
Foxl2
Location:
Chr9:98955607-98958126 bp, + strand
Genetic Position: Chr9,
51.41 cM, cytoband E4
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:87737
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Reporter) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The sequence encoding amino acids 62-375 was replaced with an in frame nls-lacZ cassette followed by a floxed neomycine resistance gene. This deletes almost the entire the forkhead/winged-helix domain. The neomycin gene was subsequently excised. Western blot analysis of protein extracts from neonatal ovaries detected only lacZ fusion proteins and not the wild-type protein. (J:87737)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Foxl2 Mutation:
|
2 strains or lines available |
|
| References |
|
Original: |
J:87737
Schmidt D et al.,
"The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance."
Development 2004 Feb;131(4):933-42
|
|
All: |
2 reference(s)
|
|
Analysis Tools
