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| Nomenclature |
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Symbol:
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Nphs2tm1Antc
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Name:
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nephrosis 2 homolog, podocin (human);
targeted mutation 1, Corinne Antignac
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MGI ID: |
MGI:3028629 |
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Synonyms: |
Nphs2- |
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Gene:
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Nphs2
Location:
Chr1:156310735-156328035 bp, + strand
Genetic Position: Chr1,
67.71 cM, cytoband G3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:87577
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1 and 2 were replaced with a floxed Pgk-hygromycin cassette inserted in reverse orientation. Absence of transcript and protein product was established by Northern blot analysis and immunofluorescence experiments respectively. (J:87577)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nphs2 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:87577
Roselli S et al.,
"Early glomerular filtration defect and severe renal disease in podocin-deficient mice."
Mol Cell Biol 2004 Jan;24(2):550-60
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All: |
3 reference(s)
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Analysis Tools
