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| Nomenclature |
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Symbol:
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Ptprctm1Weis
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Name:
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protein tyrosine phosphatase, receptor type, C;
targeted mutation 1, Arthur Weiss
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MGI ID: |
MGI:3027340 |
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Synonyms: |
CD45 E613R, Cd45w, Wedge |
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Gene:
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Ptprc
Location:
Chr1:138062861-138175305 bp, - strand
Genetic Position: Chr1,
60.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66501
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: To recapitulate a mutation in the orthologous human gene that disrupts the inhibitory wedge, a glutamate to arginine substitution at codon 613 (E613R) was engineered in exon 18 and incorporated at the endogenous locus via homolgous recombination. A single loxP site remained in intron 18 after the floxed neo cassette was excised. (J:66501)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:66501
Majeti R et al.,
"An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity."
Cell 2000 Dec 22;103(7):1059-70
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All: |
6 reference(s)
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Analysis Tools
