|
|
| Nomenclature |
|
Symbol:
|
Tg(Ins2-CD80)3B7Flv
|
|
Name:
|
transgene insertion 3B7, Richard Flavell
|
|
MGI ID: |
MGI:2682826 |
|
Synonyms: |
RIP-B7, RIP-B7-1, RIP-B7.1, RIP-CD80 |
|
Transgene:
|
Tg(Ins2-CD80)3B7Flv
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(C57BL/6 x CBA/Ca)F2
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
The transgene contains a human CD80 antigen gene driven by the rat insulin II promoter (Ins2). (J:88250)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
Mice carrying this transgene that also are homozygous for Prkdcscid are characterized by pancreatic beta cells that express a rat insulin II promoter regulated transgene encoding the human CD80 T cell co-stimulatory molecule.
|
| References |
|
Original: |
J:88250
Guerder S et al.,
"Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice."
Proc Natl Acad Sci U S A 1994 May 24;91(11):5138-42
|
|
All: |
20 reference(s)
|
|
Analysis Tools
