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| Nomenclature |
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Symbol:
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Bbc3tm1Ast
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Name:
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BCL2 binding component 3;
targeted mutation 1, Andreas Strasser
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MGI ID: |
MGI:2681654 |
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Synonyms: |
puma- |
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Gene:
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Bbc3
Location:
Chr7:16309616-16318205 bp, + strand
Genetic Position: Chr7,
8.85 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:86466
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2 and 3 which contain the BH3 interaction domain were replaced by a floxed PGK-neomycin expression cassette. The resistance cassette was removed in vivo by crossing mice to a C57BL/6 Deleter mouse line. Gene disruption was confirmed by RT-PCR and Northern blot analysis. (J:86466)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:86466
Villunger A et al.,
"p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa."
Science 2003 Nov 7;302(5647):1036-8
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All: |
36 reference(s)
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Analysis Tools
