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| Nomenclature |
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Symbol:
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Ghrtm1Arge
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Name:
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growth hormone receptor;
targeted mutation 1, Argiris Efstratiadis
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MGI ID: |
MGI:2681515 |
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Synonyms: |
Ghr-, Ghrex7-8 |
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Gene:
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Ghr
Location:
Chr15:3317760-3583492 bp, - strand
Genetic Position: Chr15,
1.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66913
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced genomic sequences including exons 7, 8a and 8. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele, and western blot analysis confirmed that no encoded protein was present in hepatic microsomal membrane extracts derived from homozygous mice. (J:66913)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ghr Mutation:
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1 strain or line available |
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| References |
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Original: |
J:66913
Lupu F et al.,
"Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth."
Dev Biol 2001 Jan 1;229(1):141-62
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All: |
1 reference(s)
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Analysis Tools
