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| Nomenclature |
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Symbol:
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Cntnap2tm1Pele
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Name:
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contactin associated protein-like 2;
targeted mutation 1, Elior Peles
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MGI ID: |
MGI:2677631 |
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Synonyms: |
Caspr2- |
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Gene:
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Cntnap2
Location:
Chr6:45060061-47301369 bp, + strand
Genetic Position: Chr6,
21.81 cM, cytoband B2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85502
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1, which contains the start codon encodes the signal peptide, was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of homozygous mutant brain RNA. Protein was undetected in the central nervous system of homozygous mutant mice by immunoprecipitation and Western blot analysis. Similarly, no specific staining was observed by immunolabeling of sciatic nerve tissue. (J:85502)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:85502
Poliak S et al.,
"Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1."
J Cell Biol 2003 Sep 15;162(6):1149-60
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All: |
7 reference(s)
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Analysis Tools
