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| Nomenclature |
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Symbol:
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Mogtm1Dpd
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Name:
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myelin oligodendrocyte glycoprotein;
targeted mutation 1, Danielle Pham-Dinh
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MGI ID: |
MGI:2675017 |
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Synonyms: |
MOG- |
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Gene:
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Mog
Location:
Chr17:37010746-37023398 bp, - strand
Genetic Position: Chr17,
19.16 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85155
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A cassette containing lacZ and neo was inserted into exon 1 seven bp upstream of the start codon. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of homozygous mutant mice. The lacZ expression pattern recapitulated that of the endogenous gene. (J:85155)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mog Mutation:
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37 strains or lines available |
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| References |
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Original: |
J:85155
Delarasse C et al.,
"Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice."
J Clin Invest 2003 Aug;112(4):544-53
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All: |
8 reference(s)
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Analysis Tools
