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| Nomenclature |
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Symbol:
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Fancd2tm1Hou
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Name:
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Fanconi anemia, complementation group D2;
targeted mutation 1, Scott Houghtaling
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MGI ID: |
MGI:2673422 |
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Synonyms: |
Fancd2- |
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Gene:
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Fancd2
Location:
Chr6:113531682-113597017 bp, + strand
Genetic Position: Chr6,
52.78 cM, cytoband E3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84892
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 220 bp encompassing exons 26 and 27 were replaced with a floxed neo-ura cassette. While RT-PCR analysis of homozygous mutant mice showed transcript lacking the targeted exons, neither normal or mutant protein arising from the detected transcript was detected by Western blot analysis. (J:84892)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fancd2 Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:84892
Houghtaling S et al.,
"Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice."
Genes Dev 2003 Aug 15;17(16):2021-35
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All: |
12 reference(s)
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Analysis Tools
