|
|
| Nomenclature |
|
Symbol:
|
Runx1t1tm1Buch
|
|
Name:
|
runt-related transcription factor 1; translocated to, 1 (cyclin D-related);
targeted mutation 1, Frank Buchholz
|
|
MGI ID: |
MGI:2671472 |
|
Synonyms: |
ETOX |
|
Gene:
|
Runx1t1
Location:
Chr4:13743436-13893649 bp, + strand
Genetic Position: Chr4,
5.88 cM, cytoband A
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:68499
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Other |
| |
|
Mutation details: A floxed neo cassette was inserted into intron 1, 893 bp upstream of exon 2. This allele was initially generated for use in the engineering of T(4;16), a reciporical translocation that replicates the human acute myeloid leukemia (AML) associated translocation, T(8;21). (J:68499)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Runx1t1 Mutation:
|
8 strains or lines available |
|
| References |
|
Original: |
J:68499
Buchholz F et al.,
"Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse."
EMBO Rep 2000 Aug;1(2):133-9
|
|
All: |
1 reference(s)
|
|
Analysis Tools
