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| Nomenclature |
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Symbol:
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Bard1tm1Thl
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Name:
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BRCA1 associated RING domain 1;
targeted mutation 1, Thomas Ludwig
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MGI ID: |
MGI:2668394 |
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Synonyms: |
Bard1- |
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Gene:
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Bard1
Location:
Chr1:71027498-71103146 bp, - strand
Genetic Position: Chr1,
35.67 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84329
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The open reading frame in exon 1 (amino acids 1-46) was replaced with a hygromycin resistance-EGFP fusion gene. Western blot analysis of E9.5 homozygous embryos proved the absence of gene product. (J:84329)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Bard1 Mutation:
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16 strains or lines available |
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| References |
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Original: |
J:84329
McCarthy EE et al.,
"Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability."
Mol Cell Biol 2003 Jul;23(14):5056-63
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All: |
2 reference(s)
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Analysis Tools
