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| Nomenclature |
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Symbol:
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Bin1tm1Gcp
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Name:
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bridging integrator 1;
targeted mutation 1, George C Prendergast
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MGI ID: |
MGI:2664484 |
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Synonyms: |
Bin1- |
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Gene:
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Bin1
Location:
Chr18:32377217-32435736 bp, + strand
Genetic Position: Chr18,
18.01 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83753
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Parent Cell Line:
| IT2 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacing the region encoding the BAR domain (part of exon 3 and all of exons 4 and 5) with a neomycin resistance cassette. Absence of gene expression was confirmed by Western blot analysis of embyronic fibrobasts derived from homozygous mutants. (J:83753)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Bin1 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:83753
Muller AJ et al.,
"Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation."
Mol Cell Biol 2003 Jun;23(12):4295-306
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All: |
3 reference(s)
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Analysis Tools
