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| Nomenclature |
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Symbol:
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Tlr9tm1Aki
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Name:
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toll-like receptor 9;
targeted mutation 1, Shizuo Akira
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MGI ID: |
MGI:2660562 |
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Synonyms: |
Tlr9-, TLR9 KO |
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Gene:
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Tlr9
Location:
Chr9:106222598-106226876 bp, + strand
Genetic Position: Chr9,
57.46 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66049
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.0 kb fragment of the gene encoding a part of a leucine-rich repeat domain was replaced with a neomycin resistance cassette. Northern blot analysis demonstrated that a mutated transcript was expressed from this allele, but this transcript is not expected to produce a functional protein.
(J:66049)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:66049
Hemmi H et al.,
"A Toll-like receptor recognizes bacterial DNA."
Nature 2000 Dec 7;408(6813):740-5
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All: |
257 reference(s)
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Analysis Tools
