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| Nomenclature |
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Symbol:
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Rpgrip1tm1Tili
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Name:
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retinitis pigmentosa GTPase regulator interacting protein 1;
targeted mutation 1, Tiansen Li
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MGI ID: |
MGI:2655714 |
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Synonyms: |
RPGRIP- |
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Gene:
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Rpgrip1
Location:
Chr14:52110903-52161307 bp, + strand
Genetic Position: Chr14,
26.81 cM
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Ultrastructural examination of Rpgrip1tm1Tili/Rpgrip1tm1Tili mouse photoreceptors
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82755
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a large cassette containing 3 duplicated exons and a neomycin resistance gene. RT-PCR and sequence analysis of mRNA from homozygous mutant animals detected a premature stop codon. Absence of gene expression in homozygous animals was confirmed by Western blot analysis. (J:82755)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rpgrip1 Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:82755
Zhao Y et al.,
"The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis."
Proc Natl Acad Sci U S A 2003 Apr 1;100(7):3965-70
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All: |
3 reference(s)
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Analysis Tools
