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| Nomenclature |
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Symbol:
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Slc1a1tm1Wst
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Name:
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solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1;
targeted mutation 1, Wilheim Stoffel
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MGI ID: |
MGI:2655190 |
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Synonyms: |
eaac-1 -, EAAC1-, EAAT3- |
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Gene:
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Slc1a1
Location:
Chr19:28835049-28913960 bp, + strand
Genetic Position: Chr19,
23.5 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:41613
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 1 by homologous recombination. Northern blot analysis demonstrated that no detectable mRNA was expressed from this allele. (J:41613)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc1a1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:41613
Peghini P et al.,
"Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration."
EMBO J 1997 Jul 1;16(13):3822-32
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All: |
17 reference(s)
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Analysis Tools
