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| Nomenclature |
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Symbol:
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Kcnh2tm1Hjd
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Name:
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potassium voltage-gated channel, subfamily H (eag-related), member 2;
targeted mutation 1, Henry J Duff
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MGI ID: |
MGI:2652959 |
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Synonyms: |
ERG1 B- |
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Gene:
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Kcnh2
Location:
Chr5:24319589-24351604 bp, - strand
Genetic Position: Chr5,
10.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82249
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An isoform specific mutation was generated by replacing the coding region of exon 1B with a floxed neomycin selection cassette. RT-PCR analysis verified that sequence upstream of the insertion, encoding the A isoform, was transcribed. Transcript encoding the B isoform was undected in homozygous mutant mice by RT-PCR analysis. (J:82249)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kcnh2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:82249
Lees-Miller JP et al.,
"Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia."
Mol Cell Biol 2003 Mar;23(6):1856-62
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All: |
1 reference(s)
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Analysis Tools
