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| Nomenclature |
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Symbol:
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Dnase2atm1Osa
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Name:
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deoxyribonuclease II alpha;
targeted mutation 1, Shigekazu Nagata
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MGI ID: |
MGI:2449811 |
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Synonyms: |
Dnase II- |
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Gene:
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Dnase2a
Location:
Chr8:84908560-84922915 bp, + strand
Genetic Position: Chr8,
41.31 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69831
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1-5 and part of exon 6 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of fetal liver RNA from E14.5 homozygous mutant embryos. No enzyme activity could be detected in homozygous mutant fetal liver extracts. (J:69831)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:69831
Kawane K et al.,
"Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver."
Science 2001 May 25;292(5521):1546-9
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All: |
10 reference(s)
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Analysis Tools
