|
|
| Nomenclature |
|
Symbol:
|
Tenc1nph
|
|
Name:
|
tensin like C1 domain-containing phosphatase;
nephrosis
|
|
MGI ID: |
MGI:2447990 |
|
Synonyms: |
nep |
|
Gene:
|
Tenc1
Location:
Chr15:102102988-102116401 bp, + strand
Genetic Position: Chr15,
57.29 cM
|
|
Mutation
origin |
|
Mutation
description |
|
Allele
Type: | |
Spontaneous |
|
Mutation: | |
Intragenic deletion |
| |
|
Mutation details: A phenotypic mutant that arose in an outbred ICR colony at the National Institute of Health (Japan) in 1986. This is the main causative gene producing nephrosis in the ICGN strain. An 8 base pair deletion in exon 18 (from nucleotide 1477 to nucleotide 1484) is predicted to result in a premature stop codon and protein truncation. Tenc1 expression is significantly decreased in all organs of ICGN animals. (J:108691)
|
|
Inheritance: | |
Recessive |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Tenc1 Mutation:
|
2 strains or lines available |
|
|
Notes |
Phenotypic Similarity to Human Syndrome: Nephrotic Syndrome (J:21656)
|
| References |
|
Original: |
J:16284
Kurosawa T et al.,
"Nephrosis (nep): a new mouse mutation which causes albuminuria and other symptoms of nephrosis"
Mouse Genome 1993;91(4):876-78
|
|
All: |
21 reference(s)
|
|
Analysis Tools
