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| Nomenclature |
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Symbol:
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Foxo1tm1Whb
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Name:
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forkhead box O1;
targeted mutation 1, William H Biggs III
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MGI ID: |
MGI:2447732 |
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Synonyms: |
Foxo1-, FoxO1+ |
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Gene:
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Foxo1
Location:
Chr3:52268337-52350109 bp, + strand
Genetic Position: Chr3,
23.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79560
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The endogenous locus was disrupted by a beta-geo cassette inserted immediately downstream of the start codon in exon 1 by homologous recombination. The deleted region included the coding region of exon 1 and approximately 3 kb of intronic sequnence. Transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:79560)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Foxo1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:79560
Nakae J et al.,
"Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1."
Nat Genet 2002 Oct;32(2):245-53
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All: |
8 reference(s)
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Analysis Tools
