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| Nomenclature |
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Symbol:
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Abcg2tm1Ahs
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Name:
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ATP-binding cassette, sub-family G (WHITE), member 2;
targeted mutation 1, Alfred H Schinkel
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MGI ID: |
MGI:2447196 |
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Synonyms: |
Abcg2-, Bcrp1- |
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Gene:
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Abcg2
Location:
Chr6:58584523-58692869 bp, + strand
Genetic Position: Chr6,
27.82 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:80519
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 5.1 kb genomic fragment encompassing exons 3 through 6 was replaced with a pgk-hygro selection cassette inserted by homologous recombination. The deleted region encoded the majority of the ATP-binding domain. The absence of normal transcript was confirmed by Northern blot analysis of homozygous mutant mice. No protein was detected by Western blot analysis or by immunohistochemical staining. (J:80519)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abcg2 Mutation:
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42 strains or lines available |
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| References |
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Original: |
J:80519
Jonker JW et al.,
"The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria."
Proc Natl Acad Sci U S A 2002 Nov 26;99(24):15649-54
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All: |
22 reference(s)
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Analysis Tools
