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| Nomenclature |
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Symbol:
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Slc11a1tm1Mcg
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Name:
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solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1;
targeted mutation 1, McGill University
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MGI ID: |
MGI:2446573 |
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Synonyms: |
Nramp1- |
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Gene:
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Slc11a1
Location:
Chr1:74375203-74386062 bp, + strand
Genetic Position: Chr1,
38.54 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28278
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 500 nt fragment containing a portion of exon 7 and all of exon 8 was replaced with a neomycin selection cassette inserted by homologous recombination. Whereas Northern blot analyses showed an absence of normal transcript, aberrant transcripts containing neo sequence were detected in homozygous mutant mice. Translation of the mutant transcripts was expected to result in truncated peptides lacking 8 of the 12 endogenous transmembrane domains. (J:28278)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc11a1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:28278
Vidal S et al.,
"The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene."
J Exp Med 1995 Sep 1;182(3):655-66
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All: |
19 reference(s)
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Analysis Tools
