Tg(KRT14-cre)1Amc
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(KRT14-cre)1Amc
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Name:
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transgene insertion 1, Andrew P McMahon
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MGI ID: |
MGI:2445832 |
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Synonyms: |
K14cre, K14 cre, K14-cre, Krt14Cre |
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Transgene:
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Tg(KRT14-cre)1Amc
Location:
unknown
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Show the 1 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The transgene is composed of a cre recombinase gene under the control of a human keratin 14 promoter. The human KRT14 promoter directs transgene expression in hair and skin. The transgene also contains a human growth hormone sequence and polyadenylation signal. When crossed to a transgenic reporter line, beta-galactosidase activity was detected in the oral ectoderm at 11.75 dpc, and at 14.5 dpc activity is detected in the skin and throughout the dental epithelium. (J:65294)
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Recombinase activity
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Activity in:
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alimentary system,
cardiovascular system,
cavities & their linings,
hemolymphoid system,
integumental system,
limbs,
liver & biliary system,
nervous system,
renal & urinary system,
reproductive system,
sensory organs
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Not detected in:
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adipose tissue,
embryo-other,
endocrine system,
extraembryonic component,
muscle,
postnatal-other,
respiratory system,
skeletal system,
tail
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Driver:
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KRT14
Summary of all recombinase alleles
driven by KRT14.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This allele is representative of 2 founders (#199 and #200) exhibiting the highest level of transgene expression. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
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| References |
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Original: |
J:65294
Dassule HR et al.,
"Sonic hedgehog regulates growth and morphogenesis of the tooth"
Development 2000 Nov;127(22):4775-85
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All: |
67 reference(s)
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Analysis Tools
