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| Nomenclature |
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Symbol:
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Pitx2tm4(cre)Jfm
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Name:
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paired-like homeodomain transcription factor 2;
targeted mutation 4, James F Martin
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MGI ID: |
MGI:2445429 |
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Synonyms: |
delta abccreneo, Pitx2-Cre, Pitx2creneo, Pitx2 delta abccreneo |
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Gene:
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Pitx2
Location:
Chr3:129199878-129219591 bp, + strand
Genetic Position: Chr3,
57.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79853
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Exon 5, which encodes a portion of the homeodomain, was disrupted by the insertion of a cassette containing IRES, cre recombinase, lacZ, and neo. In situ hybridization results showed that the expression pattern of cre was similar to that of the endogenous gene. The neo was removed by crossing to Flp-expressing mice. (J:79853, J:87220)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79853
Liu C et al.,
"Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions."
Development 2002 Nov;129(21):5081-91
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All: |
11 reference(s)
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Analysis Tools
