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| Nomenclature |
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Symbol:
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Il2rgtm1Sug
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Name:
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interleukin 2 receptor, gamma chain;
targeted mutation 1, Kazuo Sugamura
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MGI ID: |
MGI:2429736 |
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Synonyms: |
CDgamma- |
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Gene:
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Il2rg
Location:
ChrX:101264378-101268255 bp, - strand
Genetic Position: ChrX,
43.9 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:31167
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A sequence fragment containing portions of exon 7 and 8 was replaced with a neo cassette inserted by homologous recombination. The deleted region encoded the majority of the SH2-like domain. Flow cytometry and the use of labeled thymidine indicated that the mutant protein localized to the surface of thymocytes but did not transduce signals. (J:31167)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Il2rg Mutation:
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29 strains or lines available |
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Notes |
ES cell line = E14.1 (129P2/OlaHsd) or EK.CCE (129S/SvEv-Gpi1c).
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| References |
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Original: |
J:31167
Ohbo K et al.,
"Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain."
Blood 1996 Feb 1;87(3):956-67
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All: |
28 reference(s)
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Analysis Tools
