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| Nomenclature |
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Symbol:
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Irs2tm1Tka
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Name:
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insulin receptor substrate 2;
targeted mutation 1, Takashi Kadowaki
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MGI ID: |
MGI:2429574 |
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Synonyms: |
Irs2-, IRS-2- |
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Gene:
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Irs2
Location:
Chr8:10986961-11008430 bp, - strand
Genetic Position: Chr8,
5.35 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65485
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The endogenous gene was disrupted by the insertion of a neomycin selection cassette. Expression was undetected by Northern and Western blot analyses of homozygous mutant mice. (J:65485)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Irs2 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:65485
Kubota N et al.,
"Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia"
Diabetes 2000 Nov;49(11):1880-9
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All: |
18 reference(s)
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Analysis Tools
