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| Nomenclature |
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Symbol:
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Bace1tm1Pcw
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Name:
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beta-site APP cleaving enzyme 1;
targeted mutation 1, Philip C Wong
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MGI ID: |
MGI:2389228 |
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Synonyms: |
Bace1-, BACE1- |
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Gene:
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Bace1
Location:
Chr9:45838580-45864399 bp, + strand
Genetic Position: Chr9,
25.22 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79847
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant embryos. (J:79847)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79847
Cai H et al.,
"BACE1 is the major beta-secretase for generation of Abeta peptides by neurons."
Nat Neurosci 2001 Mar;4(3):233-4
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All: |
27 reference(s)
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Analysis Tools
