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| Nomenclature |
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Symbol:
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Startm1Klp
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Name:
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steroidogenic acute regulatory protein;
targeted mutation 1, Keith L Parker
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MGI ID: |
MGI:2388706 |
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Gene:
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Star
Location:
Chr8:25808474-25814723 bp, + strand
Genetic Position: Chr8,
14.17 cM
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Histology of the adrenal gland from wild type and Startm1Klp/Startm1Klp mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43589
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A portion of exon 2 and all of exon 3 were replaced with a neomycin selection cassette. Normal protein was undetected by Western blot analysis of adrenal extracts from homozygous mutant mice. (J:43589)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Star Mutation:
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1 strain or line available |
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| References |
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Original: |
J:43589
Caron KM et al.,
"Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia."
Proc Natl Acad Sci U S A 1997 Oct 14;94(21):11540-5
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All: |
7 reference(s)
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Analysis Tools
