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| Nomenclature |
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Symbol:
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Adamts2tm1Prc
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Name:
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a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2;
targeted mutation 1, Darwin J Prockop
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MGI ID: |
MGI:2388161 |
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Gene:
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Adamts2
Location:
Chr11:50602084-50807573 bp, + strand
Genetic Position: Chr11,
30.78 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69141
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exon 14 and flanking intronic sequences with a neomycin resistance cassette. Northern blot analysis of fibroblasts from homozygous mutant animals did not detect RNA transcripts of any size. (J:69141)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Adamts2 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:69141
Li SW et al.,
"Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility."
Biochem J 2001 Apr 15;355(Pt 2):271-8
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All: |
2 reference(s)
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Analysis Tools
