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| Nomenclature |
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Symbol:
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Ghrtm1Jjk
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Name:
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growth hormone receptor;
targeted mutation 1, John J Kopchick
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MGI ID: |
MGI:2388126 |
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Synonyms: |
BH-R-KO, GHR-, GHR/BP-, GHR/BP-deficient, GHRko, GHR-KO, Laron dwarf |
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Gene:
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Ghr
Location:
Chr15:3317760-3583492 bp, - strand
Genetic Position: Chr15,
1.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44604
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 4 and 500 bp of downstream intronic sequences were replaced with a neomycin resistance cassette via homologous recombination. Northern blot and RT-PCR analysis of liver mRNA from homozygous mutant animals failed to detect gene expression. Western blot analysis of homozygous mutant liver samples did not detect protein product. (J:44604)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ghr Mutation:
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1 strain or line available |
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| References |
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Original: |
J:44604
Zhou Y et al.,
"A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)."
Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13215-20
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All: |
73 reference(s)
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Analysis Tools
