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| Nomenclature |
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Symbol:
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Rad50tm2Jpt
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Name:
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RAD50 homolog (S. cerevisiae);
targeted mutation 2, John H J Petrini
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MGI ID: |
MGI:2387857 |
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Synonyms: |
Rad50K22M, Rad50S |
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Gene:
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Rad50
Location:
Chr11:53649519-53707319 bp, - strand
Genetic Position: Chr11,
31.98 cM, cytoband A5-B1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:78820
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A lysine to methionine substitution at amino acid 22 (K22M) was introduced to exon 1 via homologous recombination and a floxed puromyin resistance cassette was inserted into the upstream intron. The puromycin cassette was excised by crossing mutant animals to the cre-expressing line Tg(CMV-cre)1Nagy. (J:78820)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rad50 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:78820
Bender CF et al.,
"Cancer predisposition and hematopoietic failure in Rad50(S/S) mice."
Genes Dev 2002 Sep 1;16(17):2237-51
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All: |
5 reference(s)
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Analysis Tools
