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| Nomenclature |
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Symbol:
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Tbx5tm1.1Jse
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Name:
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T-box 5;
targeted mutation 1.1, Jonathan G Seidman
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MGI ID: |
MGI:2387851 |
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Synonyms: |
Tbx5-, Tbx5del, Tbx5delta |
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Gene:
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Tbx5
Location:
Chr5:119834663-119885218 bp, + strand
Genetic Position: Chr5,
60.42 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71845
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele is derived from Tbx5tm1Jse. The floxed exon 3 and neo cassette were removed by crossing mutant animals to the cre-expressing transgenic line TgN(EIIa-cre)C5379Lmgd. This results in deletion of the N-terminal region of the T-box encoded by exon 3. RT-PCR analysis of mutant animals detected a truncated transcript lacking exon 3. (J:71845)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tbx5 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:71845
Bruneau BG et al.,
"A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease."
Cell 2001 Sep 21;106(6):709-21
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All: |
12 reference(s)
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Analysis Tools
